Chesler Naomi C, Roldan Alejandro, Vanderpool Rebecca R, Naeije Robert
Department of Biomedical Engineering at the University of Wisconsin, Madison, WI 53706, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:177-80. doi: 10.1109/IEMBS.2009.5333835.
Long-standing pulmonary hypertension causes significant peripheral and proximal arterial remodeling and right ventricular dysfunction. The clinical metric most often used to assess the progression of PH is the pulmonary vascular resistance (PVR). However, even when measured from multipoint pressure-flow curves, PVR provides information only on the peripheral arterial function, not the proximal arterial function and gives only an incomplete description of all the forces that oppose right ventricular (RV) flow output. Pulmonary vascular impedance spectra (PVZ) capture the impact of proximal and peripheral arterial structure and function on RV function. Analyses of ventricular-vascular coupling give insight into the efficiency of mechanical and metabolic interactions between the right ventricle and the pulmonary vasculature. Here we review techniques for measuring PVZ in humans and animal models and for determining RV function.
长期的肺动脉高压会导致显著的外周和近端动脉重塑以及右心室功能障碍。临床上最常用于评估肺动脉高压进展的指标是肺血管阻力（PVR）。然而，即使通过多点压力-流量曲线进行测量，PVR也仅提供外周动脉功能的信息，而非近端动脉功能，并且只能不完全描述所有阻碍右心室（RV）血流输出的力量。肺血管阻抗谱（PVZ）可反映近端和外周动脉结构及功能对RV功能的影响。心室-血管耦合分析有助于深入了解右心室与肺血管系统之间机械和代谢相互作用的效率。在此，我们综述了在人类和动物模型中测量PVZ以及确定RV功能的技术。
