脊髓损伤患者尿道内兴奋性膀胱反射的激活
Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury.
作者信息
Yoo Paul B, Horvath Eric E, Amundsen Cindy L, Webster George D, Grill Warren M
机构信息
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6781-4. doi: 10.1109/IEMBS.2009.5333982.
Electrical activation of an excitatory reflex between sensory fibers in the pudendal nerve and the bladder has been demonstrated in cats and is a potential means of restoring micturition function in persons with spinal cord injury. We investigated the clinical feasibility of activating this reflex to restore bladder function in persons with spinal cord injury by using intraurethral electrical stimulation to activate pudendal sensory fibers innervating the urethra. Excitatory bladder responses (contractions) were evoked by trains of electrical pulses applied to either the proximal (29.7 +/- 11.6 cmH2O) or distal (30.2 +/- 11.6 cmH2O) segment of the urethra. The results indicate that an excitatory reflex between pudendal nerve afferents and the bladder exists in humans with spinal injury and may provide a substrate for restoring micturition function.
在猫身上已证实，阴部神经感觉纤维与膀胱之间存在兴奋性反射的电激活现象，这是恢复脊髓损伤患者排尿功能的一种潜在方法。我们通过使用尿道内电刺激来激活支配尿道的阴部感觉纤维，研究了激活这种反射以恢复脊髓损伤患者膀胱功能的临床可行性。向尿道近端（29.7±11.6 cmH₂O）或远端（30.2±11.6 cmH₂O）节段施加电脉冲序列，可诱发膀胱兴奋性反应（收缩）。结果表明，脊髓损伤的人类患者阴部神经传入纤维与膀胱之间存在兴奋性反射，这可能为恢复排尿功能提供基础。
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