Identification of markers of cardiovascular disease in women and the reconstruction of its corresponding protein interaction network.

Cardiovascular disease is the second most prevalent cause of morbidity and mortality in women of developed countries. Although it is well established that gender is a risk factor for cardiovascular disease, most gene expression analysis studies favour the identification of disease bio-markers and potential drug targets over combined populations. This study integrates genomic and systems approaches to identify a female-related set of genes that intervene in signal and metabolic pathways leading to cardiovascular disease.