Emamian Effat S, Abdi Ali
Advanced Technologies for Novel Therapeutics, Enterprise Development Center, Newark, NJ 07103, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1083-5. doi: 10.1109/IEMBS.2009.5334895.
The challenging nature of complex human disorders has taught us that we can not untangle a disorder unless we understand how the "engine" of molecular systems works. After learning the basic physiology of different organs in the human body, a "molecular revolution" occurred, which has now generated a huge amount of information regarding the function of individual molecules in human cells. The difficult task, however, is to understand how thousands of molecules communicate and work together to deliver a specific function, and more importantly, what goes wrong when the system fails and causes different diseases. The emerging field of systems biology is now opening the door for engineers, to join molecular biologists and enter the era of molecular biomedical engineering.
复杂人类疾病的挑战性本质让我们明白，除非我们了解分子系统的“引擎”是如何运作的，否则就无法解开一种疾病之谜。在了解了人体不同器官的基本生理机能之后，一场“分子革命”发生了，如今这场革命已经产生了大量有关人类细胞中单个分子功能的信息。然而，艰巨的任务是要弄清楚数千个分子是如何相互交流并协同发挥特定功能的，更重要的是，当系统失灵并引发各种疾病时，究竟哪里出了问题。新兴的系统生物学领域如今正在为工程师们打开大门，让他们能够与分子生物学家携手，进入分子生物医学工程时代。
