Jiang Dineng, Wu Wenqing, Jia Xiaofeng, Qiu Yihong, Zhu Yisheng, Thakor Nitish, Tong Shanbao
Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, PR China.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:2192-5. doi: 10.1109/IEMBS.2009.5334934.
Several markers based on quantitative electroencephalogram (qEEG) analysis have been associated with the neuroprotective effects of therapeutic hypothermia on hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). Nevertheless, the makers by far have not been linked to the temporal process of the ischemic neuronal death. In this study, we investigated the long-range correlations in EEG power in theta and alpha bands before and after CA by detrended fluctuation analysis (DFA). The scaling components by DFA showed that the short-term scaling exponent in alpha band (i.e. gamma(1)(alpha)) was well correlated with recovery of brain injury during the latent phase. While the short-term scaling exponent in theta band (i.e. gamma(1)(theta)) and the long-term scaling exponent in alpha band (i.e. gamma(2)(alpha)) were correlated with the delayed neuronal death after CA. Our preliminary results showed that the long-range correlations in theta and alpha bands could be related the detail temporal process of therapeutic hypothermia.
基于定量脑电图（qEEG）分析的几种标志物已与治疗性低温对心脏骤停（CA）后缺氧缺血性脑病（HIE）的神经保护作用相关联。然而，迄今为止这些标志物尚未与缺血性神经元死亡的时间进程联系起来。在本研究中，我们通过去趋势波动分析（DFA）研究了CA前后脑电图θ波和α波频段功率的长程相关性。DFA的标度成分表明，α波频段的短期标度指数（即γ(1)(α)）与潜伏期脑损伤的恢复密切相关。而θ波频段的短期标度指数（即γ(1)(θ)）和α波频段的长期标度指数（即γ(2)(α)）与CA后的延迟性神经元死亡相关。我们的初步结果表明，θ波和α波频段的长程相关性可能与治疗性低温的详细时间进程有关。
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