Jia Xiaofeng, Koenig Matthew A, Shin Hyun-Chool, Zhen Gehua, Yamashita Soichiro, Thakor Nitish V, Geocadin Romergryko G
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Brain Res. 2006 Sep 21;1111(1):166-75. doi: 10.1016/j.brainres.2006.04.121. Epub 2006 Aug 17.
We test the hypothesis that quantitative electroencephalogram (qEEG) can be used to objectively assess functional electrophysiological recovery of brain after hypothermia in an asphyxial cardiac arrest rodent model. Twenty-eight rats were randomly subjected to 7-min (n = 14) and 9-min (n = 14) asphyxia times. One half of each group (n = 7) was randomly subjected to hypothermia (T = 33 degrees C for 12 h) and the other half (n = 7) to normothermia (T = 37 degrees C). Continuous physiologic monitoring of blood pressure, EEG, and core body temperature monitoring and intermittent arterial blood gas (ABG) analysis was undertaken. Neurological recovery after resuscitation was monitored using serial Neurological Deficit Score (NDS) calculation and qEEG analysis. Information Quantity (IQ), a previously validated measure of relative EEG entropy, was employed to monitor electrical recovery. The experiment demonstrated greater recovery of IQ in rats treated with hypothermia compared to normothermic controls in both injury groups (P < 0.05). The 72-h NDS of the hypothermia group was also significantly improved compared to the normothermia group (P < 0.05). IQ values measured at 4 h had a strong correlation with the primary neurological outcome measure, 72-h NDS score (Pearson correlation 0.746, 2-tailed significance <0.001). IQ is sensitive to the acceleration of neurological recovery as measured NDS after asphyxial cardiac arrest known to occur with induced hypothermia. These results demonstrate the potential utility of qEEG-IQ to track the response to neuroprotective hypothermia during the early phase of recovery from cardiac arrest.
在窒息性心脏骤停啮齿动物模型中，定量脑电图（qEEG）可用于客观评估低温治疗后脑的功能电生理恢复情况。28只大鼠被随机分为窒息7分钟组（n = 14）和窒息9分钟组（n = 14）。每组中的一半（n = 7）被随机给予低温治疗（体温33摄氏度，持续12小时），另一半（n = 7）给予常温治疗（体温37摄氏度）。持续进行血压、脑电图和核心体温的生理监测，并进行间歇性动脉血气（ABG）分析。复苏后，通过连续计算神经功能缺损评分（NDS）和qEEG分析来监测神经功能恢复情况。采用信息熵（IQ）这一先前已验证的相对脑电图熵的测量指标来监测电生理恢复情况。实验表明，在两个损伤组中，低温治疗的大鼠与常温对照组相比，IQ的恢复情况更好（P < 0.05）。与常温组相比，低温组72小时的NDS也有显著改善（P < 0.05）。在4小时测量的IQ值与主要神经功能结局指标72小时NDS评分有很强的相关性（Pearson相关性为0.746，双侧显著性<0.001）。已知低温治疗可加速窒息性心脏骤停后神经功能的恢复，IQ对这种恢复情况很敏感。这些结果表明，qEEG-IQ在心脏骤停恢复早期阶段跟踪对神经保护性低温治疗反应方面具有潜在应用价值。
