Doğan Abdullah, Akçay Selahaddin
Süleyman Demirel Universitesi Tip Fakültesi, Kardiyoloji Anabilim Dali, Isparta, Türkiye.
Anadolu Kardiyol Derg. 2009 Dec;9(6):505-11.
The renin-angiotensin system (RAS) can play an important role as the underlying mechanism for the development and recurrence of atrial fibrillation (AF). In addition, AF itself can lead to atrial structural and/or electrophysiologic remodeling by activating the RAS. This remodeling serves as an arrhythmogenic substrate for AF. Thus, the inhibition of RAS with angiotensin converting-enzyme inhibitor or angiotensin receptor blockers may be a strategy to prevent occurrence and recurrence of AF in certain patients such as those with heart failure and hypertension in associated with left ventricular hypertrophy. In addition, it may facilitate the cardioversion of AF. In this review, we overview the effect of RAS blockers on cardioversion success and recurrence of AF.
肾素-血管紧张素系统（RAS）作为心房颤动（AF）发生和复发的潜在机制可发挥重要作用。此外，AF本身可通过激活RAS导致心房结构和/或电生理重塑。这种重塑充当了AF的致心律失常基质。因此，使用血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂抑制RAS可能是预防某些患者（如伴有左心室肥厚的心力衰竭和高血压患者）发生AF和复发的一种策略。此外，它可能有助于AF的复律。在本综述中，我们概述了RAS阻滞剂对AF复律成功率和复发的影响。
