fpr 是一种来自沙门氏菌质粒的 Xer 重组位点缺陷型，不能通过二聚体解析赋予稳定性：与 pJHCMW1 mwr 位点的比较研究。
fpr, a deficient Xer recombination site from a Salmonella plasmid, fails to confer stability by dimer resolution: comparative studies with the pJHCMW1 mwr site.
机构信息
Division of Molecular Genetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
出版信息
J Bacteriol. 2010 Feb;192(3):883-7. doi: 10.1128/JB.01082-09. Epub 2009 Dec 4.
Abstract
Salmonella plasmid pFPTB1 includes a Tn3-like transposon and a Xer recombination site, fpr, which mediates site-specific recombination at efficiencies lower than those required for stabilizing a plasmid by dimer resolution. Mutagenesis and comparative studies with mwr, a site closely related to fpr, indicate that there is an interdependence of the sequences in the XerC binding region and the central region in Xer site-specific recombination sites.
摘要
沙门氏菌质粒 pFPTB1 包含一个类似于 Tn3 的转座子和 Xer 重组位点 fpr，该位点介导的位点特异性重组效率低于通过二聚体解析稳定质粒所需的效率。与 mwr（与 fpr 密切相关的位点）的诱变和比较研究表明，Xer 位点特异性重组位点中 XerC 结合区域和中心区域的序列存在相互依赖性。
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