Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA.
Int J Toxicol. 2009 Nov-Dec;28(6 Suppl):162S-74S. doi: 10.1177/1091581809350933.
PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance ingredients and/or solvents at concentrations of 0.4% to 2%. Propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure, but the inhalation toxicity of PPG-2 methyl ether vapor, for example, is low. Aerosols, such as found with hair sprays, produce particle sizes that are not respirable. Because these ingredients are highly water-soluble, they are likely to be absorbed through the human skin only at slow rates, resulting in low blood concentrations and rapid removal by the kidney. These ingredients are not genotoxic and are not reproductive or developmental toxicants. Overall the data are sufficient to conclude that PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are safe as used in cosmetics.
PPG-2 甲醚、PPG-3 甲醚和 PPG-2 甲醚醋酸酯在化妆品中用作香料成分和/或溶剂，浓度为 0.4%至 2%。当通过吸入或口服暴露引入时，丙二醇醚会迅速被吸收并分布到全身，但例如，PPG-2 甲醚蒸气的吸入毒性较低。气雾剂，如发胶中发现的那样，产生不可呼吸的颗粒大小。由于这些成分具有高水溶性，因此它们可能仅以缓慢的速度通过人体皮肤吸收，导致血液浓度低，并迅速被肾脏清除。这些成分没有遗传毒性，也不是生殖或发育毒物。总的来说，这些数据足以得出结论，即在化妆品中使用 PPG-2 甲醚、PPG-3 甲醚和 PPG-2 甲醚醋酸酯是安全的。
