Brundin T, Wahren J
Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.
Am J Physiol. 1991 Feb;260(2 Pt 1):E232-7. doi: 10.1152/ajpendo.1991.260.2.E232.
Pulmonary, splanchnic, and interscapular O2 uptake was studied in 14 male volunteers before and for 90 min after a mixed meal. Thermistor catheters were inserted into a hepatic vein, the azygous vein, the pulmonary artery, and the aorta. Systemic and regional blood flows were determined during indirect calorimetry measurements and recordings of blood temperature. After the meal, pulmonary O2 uptake rose by 33-49 ml/min and splanchnic O2 uptake increased by 16-25 ml/min. In the azygous region O2 uptake did not increase significantly. Cardiac output increased after the meal by 1.1-1.5 l/min and splanchnic blood flow rose by 0.4-0.9 l/min. Azygous venous blood flow increased from 130 +/- 19 ml/min to 163 +/- 23 ml/min. In relation to splanchnic O2 uptake, the blood-drained splanchnic heat was low, 11 +/- 1 J/ml, and decreased to 7 +/- 1 J/ml after the meal. We conclude that after a mixed meal approximately one-half of the rise in O2 uptake occurs in the splanchnic organs; azygous-drained tissues, including possible interscapular brown adipose tissue, contribute minimally. The amount of heat drained with blood from the splanchnic region was low in relation to the splanchnic O2 uptake, indicating that splanchnic heat may be dissipated by routes other than the perfusing blood.
在14名男性志愿者进食混合餐之前及之后90分钟，对其肺部、内脏及肩胛间的氧气摄取情况进行了研究。将热敏电阻导管插入肝静脉、奇静脉、肺动脉和主动脉。在间接测热法测量和记录血液温度的过程中测定全身和局部血流量。进食后，肺部氧气摄取量每分钟增加33 - 49毫升，内脏氧气摄取量增加16 - 25毫升/分钟。在奇静脉区域，氧气摄取量没有显著增加。进食后心输出量每分钟增加1.1 - 1.5升，内脏血流量增加0.4 - 0.9升/分钟。奇静脉血流量从130±19毫升/分钟增加到163±23毫升/分钟。相对于内脏氧气摄取量，从内脏引流的血液带走的热量较低，为11±1焦耳/毫升，进食后降至7±1焦耳/毫升。我们得出结论，进食混合餐后，大约一半的氧气摄取量增加发生在内脏器官；包括可能的肩胛间棕色脂肪组织在内的奇静脉引流组织贡献极小。相对于内脏氧气摄取量，从内脏区域随血液带走的热量较少，这表明内脏热量可能通过除灌注血液之外的途径散失。
