Sim Meng-Kwoon, Wong Yong-Chiat, Xu Xiao-Guang, Sim Sai-Zhen, Tsi Daniel
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Biosci Biotechnol Biochem. 2009 Dec;73(12):2583-8. doi: 10.1271/bbb.90328. Epub 2009 Dec 7.
This study researched the effects of chicken meat extract on blood glucose and insulin level, membrane glucose transporter-4 (GLUT4), and tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) in type 2 diabetic KKAy mice and GK rats. Eight-week-old KKAy mice and GK rats and euglycemic control animals, C57BL/6J mice and Wistar rats, were orally administered a liquid commercial chicken meat extract, BRAND'S Essence of Chicken (BEC), for up to 8 weeks. BEC (1.5 ml/kg) had no effect on blood insulin levels, but significantly lessened the hyperglycemia in the diabetic animals. In the BEC-treated diabetic animals, insulin induced a significant increase in plasma membrane GLUT4 and cytosolic tyrosine-phosphorylated IRS-1, indicating that it attenuates insulin resistance. The present findings are the first demonstration of the hypoglycemic action of a dietary protein, and they lend credence to the reported benefits of using chicken meat as a source of protein in the dietary management of diabetic individuals.
本研究探讨了鸡肉提取物对2型糖尿病KKAy小鼠和GK大鼠血糖、胰岛素水平、膜葡萄糖转运蛋白4（GLUT4）以及胰岛素受体底物1（IRS-1）酪氨酸磷酸化的影响。给8周龄的KKAy小鼠、GK大鼠以及血糖正常的对照动物C57BL/6J小鼠和Wistar大鼠口服市售液态鸡肉提取物“鹰牌花旗参鸡汤”（BEC），持续8周。BEC（1.5毫升/千克）对血液胰岛素水平无影响，但显著减轻了糖尿病动物的高血糖症状。在接受BEC治疗的糖尿病动物中，胰岛素可使质膜GLUT4和胞质酪氨酸磷酸化IRS-1显著增加，表明它减轻了胰岛素抵抗。本研究结果首次证明了一种膳食蛋白具有降血糖作用，也为将鸡肉作为蛋白质来源用于糖尿病患者饮食管理的报道益处提供了证据。
