Nakamura Masamoto, Kobashikawa Kasen, Tamura Jiro, Takaki Ryo, Ohshiro Masaru, Matayoshi Ryoji, Hirata Tetsuo, Kinjyo Fukunori, Fujita Jiro
Department of Internal Medicine, Okinawa Red Cross Hospital, Japan.
Nihon Shokakibyo Gakkai Zasshi. 2009 Dec;106(12):1744-50.
A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 microg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.
一名79岁患有结肠癌并伴有多处肝转移的女性因全身化疗入住我院。她接受了第一周期的改良FOLFOX6化疗。在治疗第5天时出现意识模糊。血液检查显示其血清氨水平为121微克/分升。我们诊断为5-氟尿嘧啶（5FU）诱导的高氨血症。保守治疗使精神状态得到改善。5FU给药后发生高氨血症的原因是5FU代谢产物产生过量铵。
