Sekoguchi Satoru, Okuyama Yusuke, Enoki Yasuyuki, Kawakami Takumi, Tomie Akira, Yamada Nobuhisa, Yoriki Hiroyuki, Fukui Akifumi, Hattori Takeshi, Kamata Kazuhiro, Tomatsuri Naoya, Nakamura Hideki, Sato Hideki, Kimura Hiroyuki, Yoshida Norimasa, Shioaki Yasuhiro, Fujimoto Sotaro
Department of Gastroenterology, Kyoto First Red Cross Hospital, Japan.
Nihon Shokakibyo Gakkai Zasshi. 2009 Dec;106(12):1751-7.
A 64-year-old man was admitted to our hospital with anal pain on evacuation. MRI revealed a large rectal submucosal tumor, more than 6 cm in diameter. Fine needle histological diagnosis indicated GIST with moderate risk. The patient was treated with imatinib mesylate in order to preserve the anus. The anal pain and tumor size decreased. Trans-anal local excision was performed. This case suggests that imatinib mesylate can make it possible to treat large rectal GIST cases by preserving anus, if neoadjuvant chemotherapy can be effective.
一名64岁男性因排便时肛门疼痛入院。磁共振成像（MRI）显示一个直径超过6厘米的直肠黏膜下大肿瘤。细针组织学诊断为中度风险的胃肠道间质瘤（GIST）。为保留肛门，该患者接受了甲磺酸伊马替尼治疗。肛门疼痛和肿瘤大小均减小。随后进行了经肛门局部切除。该病例表明，如果新辅助化疗有效，甲磺酸伊马替尼可以通过保留肛门来治疗大型直肠GIST病例。
