Fukuda Shin-ichiro, Yano Koji, Ohata Kazuyuki, Nonaka Koichi, Tateyama Masakuni, Taura Naota, Komori Atsumasa, Abiru Seigo, Yatsuhashi Hiroshi, Ito Masahiro, Fujioka Hikaru, Ishibashi Hiromi
Department of Gastroenterology and Hepatology, National Hospital Organization Nagasaki Medical Center, Japan.
Nihon Shokakibyo Gakkai Zasshi. 2009 Dec;106(12):1770-7.
A 47-year-old otherwise healthy woman, presented elevation of alpha fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) levels at a general health checkup. Both HCV antibody and hepatitis B surface antigen were negative. A screening abdominal CT revealed no abnormal change. An abdominal MRI and repeated CT, however, revealed a 20-mm tumor adjacent to the inferior vena cava and adjacent to or involving the liver. A surgical resection of the tumor was performed. The tumor was adjacent to, but distinct from, the liver. The Capsule of the tumor was connected to the liver but it was distinct from hepatic, renal, and adrenal tissue. A histological examination yielded a diagnosis of moderately differentiated hepatocellular carcinoma, with positive staining of hepatocyte-specific antigen and AFP.
一名47岁的健康女性在一次常规体检中发现甲胎蛋白(AFP)和异常凝血酶原(DCP)水平升高。丙肝抗体和乙肝表面抗原均为阴性。腹部CT筛查未发现异常变化。然而,腹部MRI及重复CT检查发现,下腔静脉旁有一个20毫米的肿瘤,与肝脏相邻或累及肝脏。遂对该肿瘤进行了手术切除。肿瘤与肝脏相邻,但与肝脏不同。肿瘤包膜与肝脏相连,但与肝、肾和肾上腺组织不同。组织学检查诊断为中度分化肝细胞癌,肝细胞特异性抗原和AFP染色呈阳性。