Center for Asian Traditional Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Tohoku J Exp Med. 2009 Dec;219(4):319-30. doi: 10.1620/tjem.219.319.
Daikenchuto is a traditional herbal medicine that is used for the treatment of cold feeling in the abdomen, while Orengedokuto, also a traditional herbal medicine, is used for treating inflammatory and ulcerative diseases affecting internal organs. However, the effects of these herbal medicines on cardiac output (CO) and intestinal blood flow have never been investigated. This examiner-blinded randomized crossover study intended to clarify the influence of Daikenchuto and Orengedokuto on CO and blood flow volume in the superior mesenteric artery (SMA). Fourteen healthy men (35 +/- 7 years old) were randomly assigned to two groups: group A and group B. Initially, all subjects were given 50 ml of water orally. After 7 days, subjects in group A were given 5.0 g of Daikenchuto, and 7 days later they were given 2.5 g of Orengedokuto. These herbal medicines were given to group B subjects in the reverse order. CO and SMA blood flow volume were measured from rest to 90 min after the administration of water or each medicine. There was a significant increase in SMA blood flow volume after the administration of Daikenchuto, compared to water alone (p < 0.05) and Orengedokuto (p < 0.05). SMA blood flow volume was significantly increased between 5 and 90 min after administration of Daikenchuto (p < 0.01) compared to the resting state. However, there was no significant change in CO after the administration of either agent. The present study indicates that Daikenchuto increases SMA blood flow volume without increasing CO.
大建中汤是一种传统的草药，用于治疗腹部寒冷感，而黄耆建中汤也是一种传统的草药，用于治疗影响内脏的炎症和溃疡性疾病。然而，这些草药对心输出量（CO）和肠系膜上动脉（SMA）血流体积的影响从未被研究过。本研究旨在阐明大建中汤和黄耆建中汤对 CO 和 SMA 血流体积的影响。14 名健康男性（35±7 岁）被随机分为两组：A 组和 B 组。所有受试者最初均口服 50ml 水。7 天后，A 组受试者给予 5.0g 大建中汤，7 天后给予 2.5g 黄耆建中汤。这些草药以相反的顺序给予 B 组受试者。在给予水或每种药物后，从休息状态测量 CO 和 SMA 血流体积，直至 90 分钟。与单独给予水（p<0.05）和黄耆建中汤（p<0.05）相比，给予大建中汤后 SMA 血流体积显著增加。与静息状态相比，给予大建中汤后 5 至 90 分钟内 SMA 血流体积显著增加（p<0.01）。然而，两种药物给药后 CO 均无明显变化。本研究表明，大建中汤可增加 SMA 血流体积而不增加 CO。
