Rahman Selina, Hu Howard, McNeely Eileen, Rahman Saleh M M, Krieger Nancy, Waterman Pamela, Peters Junenette, Harris Cynthia, Harris Cynthia H, Prothrow-Stith Deborah, Gibbs Brian K, Brown Perry C, Johnson Genita, Burgess Angela, Gragg Richard D
Environmental Sciences Institute, Florida A&M University, Tallahassee, FL.
Fla Public Health Rev. 2008 Jan 1;5:64-72. doi: 10.1901/jaba.2008.5-64.
This study tests the hypothesis that disparities of hypertension risk in African Americans is related to lead exposure, perceptions of racism, and stress, among urban (Roxbury, MA) and rural (Gadsden, FL) communities. Analysis of preliminary data from Phase I reveal 60% in Gadsden and 39% in Roxbury respondents self-reported having hypertension. In Gadsden 80% people did not know if their residence contained lead paint, compared to 45% in Roxbury. In Gadsden County, 58% of respondents reported experiencing racial discrimination in different settings compared with 72% in Roxbury. In regression analyses high cholesterol emerged as a significant predictors of hypertension in Gadsden County (OR=8.29, CI=1.4-49.3), whereas monthly household income (OR=0.15, CI=0.04-0.7) and diabetes (OR=6.06, CI=1.4-26.17) were significant predictors of hypertension in Roxbury after adjusting for other covariates. These preliminary findings set the stage for initiating Phase II (Phase I continues recruitment), that entail biological marker measurements to rigorously test main hypothesis.
在城市（马萨诸塞州罗克斯伯里）和农村（佛罗里达州加兹登）社区中，非裔美国人高血压风险的差异与铅暴露、种族主义观念及压力有关。对第一阶段初步数据的分析显示，加兹登60%的受访者以及罗克斯伯里39%的受访者自我报告患有高血压。在加兹登，80%的人不知道其住所是否含有铅漆，而在罗克斯伯里这一比例为45%。在加兹登县，58%的受访者报告在不同场合遭受过种族歧视，而在罗克斯伯里这一比例为72%。在回归分析中，高胆固醇成为加兹登县高血压的一个显著预测因素（比值比=8.29，置信区间=1.4 - 49.3），而在调整其他协变量后，家庭月收入（比值比=0.15，置信区间=0.04 - 0.7）和糖尿病（比值比=6.06，置信区间=1.4 - 26.17）是罗克斯伯里高血压的显著预测因素。这些初步发现为启动第二阶段研究（第一阶段继续招募）奠定了基础，第二阶段将进行生物标志物测量以严格检验主要假设。
