Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea.
Korean J Physiol Pharmacol. 2008 Aug;12(4):205-9. doi: 10.4196/kjpp.2008.12.4.205. Epub 2008 Aug 31.
Recently, Sun et al (2008) reported that the IL6R polymorphism is associated with schizophrenia. Therefore, to detect the association between polymorphisms of interleukin 31 receptor A (IL31RA) and schizophrenia, we genotyped 9 SNPs [rs9292101 (intron 1), rs1009639 (exon 2, Pro43Pro), rs2161582 (intron 2), rs68761890 (intron 5), rs16884629 (intron 6), rs11956465 (intron 12), rs12153724 (intron 12), and rs16884641 (intron 14)] using the Golden Gate assay on Illumina BeadStation 500 GX. Two hundred eighteen patients with schizophrenia and 379 normal subjects were recruited. Patients with schizophrenia were diagnosed according to DSM-IV, and control subjects without history of psychiatric disorders were selected. We used SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs for the evaluation of genetic data. Of nine polymorphisms, three SNPs (rs9292101, rs1009639, and rs11956465) were associated with schizophrenia. The rs9292101 and rs11956465 showed significant associations with the risk of schizophrenia in the codominant [rs9292101, odds ratio (OR)=0.74, 95% confidence interval (CI)=0.580.95, p=0.017] and recessive (rs11956465, OR=0.64, 95% CI=0.420.96, p=0.034) models, respectively. The rs1009639 also was statistically related to schizophrenia in both codominant (OR=0.76, 95% CI=0.600.97, p=0.025) and dominant (OR=0.66, 95% CI=0.440.98, p=0.035) models. Two linkage disequilibrium (LD) blocks were made. In the analysis of haplotypes, a haplotype (GCT) in block 1 and a haplotype (CCACAG) in block 2 showed significant associations between schizophrenia and control groups (haplotype GCT, frequency=0.509, chi square=4.199, p=0.040; haplotype CCACAG, frequency=0.289, chi square=5.691, p=0.017). The results suggest that IL31RA may be associated with risk of schizophrenia in Korean population.
最近，Sun 等人（2008 年）报道 IL6R 多态性与精神分裂症有关。因此，为了检测白细胞介素 31 受体 A（IL31RA）多态性与精神分裂症之间的关联，我们使用 Illumina BeadStation 500 GX 的 Golden Gate 测定法对 9 个单核苷酸多态性（SNP）[rs9292101（内含子 1），rs1009639（外显子 2，Pro43Pro），rs2161582（内含子 2），rs68761890（内含子 5），rs16884629（内含子 6），rs11956465（内含子 12），rs12153724（内含子 12）和 rs16884641（内含子 14）]进行了基因分型。招募了 218 名精神分裂症患者和 379 名正常对照。根据 DSM-IV 对精神分裂症患者进行诊断，选择无精神病史的正常对照。我们使用 SNPStats、Haploview、HapAnalyzer、SNPAnalyzer 和 Helixtree 程序评估遗传数据。在这 9 个多态性中，有 3 个 SNP（rs9292101、rs1009639 和 rs11956465）与精神分裂症有关。rs9292101 和 rs11956465 在共显性[rs9292101，优势比（OR）=0.74，95%置信区间（CI）=0.580.95，p=0.017]和隐性（rs11956465，OR=0.64，95%CI=0.420.96，p=0.034）模型中与精神分裂症的风险具有显著相关性。rs1009639 在共显性（OR=0.76，95%CI=0.600.97，p=0.025）和显性（OR=0.66，95%CI=0.440.98，p=0.035）模型中也与精神分裂症有统计学关系。确定了两个连锁不平衡（LD）块。在单倍型分析中，块 1 中的单倍型（GCT）和块 2 中的单倍型（CCACAG）在精神分裂症组和对照组之间显示出显著关联（单倍型 GCT，频率=0.509，卡方=4.199，p=0.040；单倍型 CCACAG，频率=0.289，卡方=5.691，p=0.017）。结果表明，IL31RA 可能与韩国人群精神分裂症的风险有关。
