• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Glutathione reductase and thioredoxin reductase: novel antioxidant enzymes from Plasmodium berghei.谷胱甘肽还原酶和硫氧还蛋白还原酶：来自伯氏疟原虫的新型抗氧化酶。
Korean J Parasitol. 2009 Dec;47(4):421-4. doi: 10.3347/kjp.2009.47.4.421. Epub 2009 Dec 1.
2
Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite.体内两种主要的 NADPH 依赖型二硫键还原酶在疟原虫中的作用的分子遗传学证据。
J Biol Chem. 2010 Nov 26;285(48):37388-95. doi: 10.1074/jbc.M110.123323. Epub 2010 Sep 19.
3
Changes in rodent-erythrocyte methemoglobin reductase system produced by two malaria parasites, viz. Plasmodium yoelii nigeriensis and Plasmodium berghei.两种疟原虫，即约氏疟原虫尼日尔株和伯氏疟原虫对啮齿动物红细胞高铁血红蛋白还原酶系统的影响。
Comp Biochem Physiol B Biochem Mol Biol. 2001 Jul;129(4):725-31. doi: 10.1016/s1096-4959(01)00326-8.
4
Double-drug development against antioxidant enzymes from Plasmodium falciparum.针对恶性疟原虫抗氧化酶的双药研发。
Redox Rep. 2003;8(5):280-3. doi: 10.1179/135100003225002916.
5
Redox and antioxidant systems of the malaria parasite Plasmodium falciparum.恶性疟原虫的氧化还原与抗氧化系统
Mol Microbiol. 2004 Sep;53(5):1291-305. doi: 10.1111/j.1365-2958.2004.04257.x.
6
Identification of GR and TrxR systems in Setaria cervi: Purification and characterization of glutathione reductase.丝状线虫体内谷胱甘肽还原酶和硫氧还蛋白还原酶系统的鉴定：谷胱甘肽还原酶的纯化与特性分析
Parasitol Int. 2013 Apr;62(2):193-8. doi: 10.1016/j.parint.2012.12.008. Epub 2013 Jan 8.
7
Thioredoxin and glutathione systems in Plasmodium falciparum.疟原虫中的硫氧还蛋白和谷胱甘肽系统。
Int J Med Microbiol. 2012 Oct;302(4-5):187-94. doi: 10.1016/j.ijmm.2012.07.007. Epub 2012 Aug 29.
8
Glutathione and peroxide metabolism in malaria-parasitized erythrocytes.疟原虫感染红细胞中的谷胱甘肽和过氧化物代谢
Parasitol Res. 1987;73(6):515-7. doi: 10.1007/BF00535325.
9
GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR.谷胱甘肽还原酶（GSR）对于维持小鼠耳蜗中的抗氧化防御并非必不可少：硫氧还蛋白系统作为GSR功能备份的可能作用。
PLoS One. 2017 Jul 7;12(7):e0180817. doi: 10.1371/journal.pone.0180817. eCollection 2017.
10
Effects of 5,8-dimethylthieno[2,3-b]quinoline-2-carboxylic acid on the antioxidative defense and lipid membranes in Plasmodium berghei-infected erythrocytes.5,8-二甲基噻吩并[2,3-b]喹啉-2-羧酸对伯氏疟原虫感染红细胞的抗氧化防御和脂质膜的影响。
Exp Parasitol. 2015 Aug;155:26-34. doi: 10.1016/j.exppara.2015.04.026. Epub 2015 May 5.

引用本文的文献

1
Increased Blood Concentrations of Malondialdehyde in Infection: A Systematic Review and Meta-Analysis.感染中丙二醛血液浓度升高：一项系统评价和荟萃分析。
Antioxidants (Basel). 2023 Jul 27;12(8):1502. doi: 10.3390/antiox12081502.
2
Differential Effect of Antioxidants Glutathione and Vitamin C on the Hepatic Injuries Induced by ANKA Infection.抗氧化剂谷胱甘肽和维生素 C 对 ANKA 感染引起的肝损伤的影响差异。
Biomed Res Int. 2021 Sep 4;2021:9694508. doi: 10.1155/2021/9694508. eCollection 2021.
3
Genome-Wide CRISPR/Cas9 Screen Identifies New Genes Critical for Defense Against Oxidant Stress in .全基因组CRISPR/Cas9筛选鉴定出对抵御氧化应激至关重要的新基因 。 （你提供的原文似乎不完整，句末缺少具体物种等信息）
Front Microbiol. 2021 Jun 7;12:670705. doi: 10.3389/fmicb.2021.670705. eCollection 2021.
4
Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice.肝内胆汁淤积性黄疸的间日疟患者的脂质过氧化和抗氧化酶活性。
Malar J. 2013 Sep 10;12:315. doi: 10.1186/1475-2875-12-315.

本文引用的文献

1
Redox and antioxidant systems of the malaria parasite Plasmodium falciparum.恶性疟原虫的氧化还原与抗氧化系统
Mol Microbiol. 2004 Sep;53(5):1291-305. doi: 10.1111/j.1365-2958.2004.04257.x.
2
Linked thioredoxin-glutathione systems in platyhelminths.扁形动物中的硫氧还蛋白-谷胱甘肽连接系统
Trends Parasitol. 2004 Jul;20(7):340-6. doi: 10.1016/j.pt.2004.05.002.
3
Innate immunity to malaria.疟疾的天然免疫
Nat Rev Immunol. 2004 Mar;4(3):169-80. doi: 10.1038/nri1311.
4
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
5
Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages.
J Biol Chem. 2002 Jul 19;277(29):25970-5. doi: 10.1074/jbc.M203539200. Epub 2002 May 9.
6
The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited.恶性疟原虫的硫氧还蛋白系统。重新审视谷胱甘肽还原作用。
J Biol Chem. 2000 Dec 22;275(51):40180-6. doi: 10.1074/jbc.M007633200.
7
Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine.牛肾上腺皮质中的线粒体硫氧还蛋白还原酶：其纯化、性质、核苷酸/氨基酸序列及硒代半胱氨酸的鉴定
Eur J Biochem. 1999 Aug;264(1):74-84. doi: 10.1046/j.1432-1327.1999.00578.x.
8
The malaria parasite supplies glutathione to its host cell--investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum.疟原虫向其宿主细胞提供谷胱甘肽——对感染恶性疟原虫的人类红细胞中谷胱甘肽转运和代谢的研究。
Eur J Biochem. 1997 Dec 15;250(3):670-9. doi: 10.1111/j.1432-1033.1997.00670.x.
9
Glutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria.
Eur J Biochem. 1996 Jan 15;235(1-2):345-50. doi: 10.1111/j.1432-1033.1996.00345.x.
10
Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum.恶性疟原虫感染红细胞中活性氧的来源。
Mol Biochem Parasitol. 1993 Oct;61(2):231-41. doi: 10.1016/0166-6851(93)90069-a.

谷胱甘肽还原酶和硫氧还蛋白还原酶：来自伯氏疟原虫的新型抗氧化酶。

Glutathione reductase and thioredoxin reductase: novel antioxidant enzymes from Plasmodium berghei.

作者信息

Kapoor Gaurav, Banyal Harjeet Singh

机构信息

Laboratory of Parasitology and Immunology, Department of Biosciences, Himachal Pradesh University, Shimla 171005, India.

出版信息

Korean J Parasitol. 2009 Dec;47(4):421-4. doi: 10.3347/kjp.2009.47.4.421. Epub 2009 Dec 1.

DOI:10.3347/kjp.2009.47.4.421
PMID:19967095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2788726/
Abstract

Malaria parasites adapt to the oxidative stress during their erythrocytic stages with the help of vital thioredoxin redox system and glutathione redox system. Glutathione reductase and thioredoxin reductase are important enzymes of these redox systems that help parasites to maintain an adequate intracellular redox environment. In the present study, activities of glutathione reductase and thioredoxin reductase were investigated in normal and Plasmodium berghei-infected mice red blood cells and their fractions. Activities of glutathione reductase and thioredoxin reductase in P. berghei-infected host erythrocytes were found to be higher than those in normal host cells. These enzymes were mainly confined to the cytosolic part of cell-free P. berghei. Full characterization and understanding of these enzymes may promise advances in chemotherapy of malaria.

摘要

疟原虫在其红细胞阶段借助重要的硫氧还蛋白氧化还原系统和谷胱甘肽氧化还原系统来适应氧化应激。谷胱甘肽还原酶和硫氧还蛋白还原酶是这些氧化还原系统的重要酶类，有助于疟原虫维持适当的细胞内氧化还原环境。在本研究中，对正常和感染伯氏疟原虫的小鼠红细胞及其组分中的谷胱甘肽还原酶和硫氧还蛋白还原酶活性进行了研究。发现感染伯氏疟原虫的宿主红细胞中谷胱甘肽还原酶和硫氧还蛋白还原酶的活性高于正常宿主细胞中的活性。这些酶主要局限于无细胞伯氏疟原虫的胞质部分。对这些酶的全面表征和理解可能为疟疾化疗带来进展。