Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
Cardiovasc Intervent Radiol. 2010 Feb;33(1):143-9. doi: 10.1007/s00270-009-9769-2. Epub 2009 Dec 5.
To evaluate the efficacy of radiofrequency lung ablation with transbronchial saline injection. The bilateral lungs of eight living swine were used. A 13-gauge bone biopsy needle was inserted percutaneously into the lung, and 1 ml of muscle paste was injected to create a tumor mimic. In total, 21 nodules were ablated. In the saline injection group (group A), radiofrequency ablation (RFA) was performed for 11 nodules after transbronchial saline injection under balloon occlusion with a 2-cm active single internally cooled electrode. In the control group (group B), conventional RFA was performed for 10 nodules as a control. The infused saline liquid showed a wedge-shaped and homogeneous distribution surrounding a tumor mimic. All 21 RFAs were successfully completed. The total ablation time was significantly longer (13.4 +/- 2.8 min vs. 8.9 +/- 3.5 min; P = 0.0061) and the tissue impedance was significantly lower in group A compared with group B (73.1 +/- 8.8 Omega vs. 100.6 +/- 16.6 Omega; P = 0.0002). The temperature of the ablated area was not significantly different (69.4 +/- 9.1 degrees C vs. 66.0 +/- 7.9 degrees C; P = 0.4038). There was no significant difference of tumor mimic volume (769 +/- 343 mm(3) vs. 625 +/- 191 mm(3); P = 0.2783). The volume of the coagulated area was significantly larger in group A than in group B (3886 +/- 1247 mm(3) vs. 2375 +/- 1395 mm(3); P = 0.0221). Percutaneous radiofrequency lung ablation combined with transbronchial saline injection can create an extended area of ablation.
评估经支气管盐水注射射频肺消融的疗效。使用 8 头活猪的双侧肺。经皮穿刺插入 13 号骨活检针，注射 1 毫升肌肉糊以模拟肿瘤。共消融 21 个结节。在盐水注射组（A 组）中，在球囊阻塞下经支气管注射盐水后，用 2cm 主动单内冷电极对 11 个结节进行射频消融（RFA）。在对照组（B 组）中，作为对照对 10 个结节进行常规 RFA。注入的盐水液体呈楔形均匀分布，环绕肿瘤模拟物。所有 21 个射频消融均成功完成。总消融时间明显延长（13.4+/-2.8min 比 8.9+/-3.5min；P=0.0061），A 组组织阻抗明显低于 B 组（73.1+/-8.8Ω比 100.6+/-16.6Ω；P=0.0002）。消融区域的温度无明显差异（69.4+/-9.1°C 比 66.0+/-7.9°C；P=0.4038）。肿瘤模拟物体积无明显差异（769+/-343mm3 比 625+/-191mm3；P=0.2783）。A 组凝固区体积明显大于 B 组（3886+/-1247mm3 比 2375+/-1395mm3；P=0.0221）。经皮射频肺消融联合经支气管盐水注射可扩大消融面积。
