Dietert Rodney R, Dewitt Jamie
Methods Mol Biol. 2010;598:17-25. doi: 10.1007/978-1-60761-401-2_2.
Developmental immunotoxicity (DIT) has emerged as a serious health consideration given the increases in the prevalence of many immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes. As a result, the use of DIT testing to identify potential environmental risk factors contributing to these and other diseases has become a higher priority. This introductory chapter considers: (1) the basis for an increased and earlier use of DIT testing in safety evaluations and (2) the general features of DIT testing strategies designed to reduce health risks.
鉴于许多基于免疫的儿童疾病和病症的患病率不断上升，包括过敏性疾病和哮喘、复发性中耳炎、小儿乳糜泻和1型糖尿病，发育免疫毒性（DIT）已成为一个严重的健康问题。因此，使用DIT测试来识别导致这些疾病和其他疾病的潜在环境风险因素已成为更高的优先事项。本章引言部分探讨了：（1）在安全性评估中增加和更早使用DIT测试的依据，以及（2）旨在降低健康风险的DIT测试策略的一般特征。
