Burleson Florence G, Burleson Gary R
Methods Mol Biol. 2010;598:97-108. doi: 10.1007/978-1-60761-401-2_7.
Immunotoxicity testing is used to provide safety assessment with the major objective being the avoidance of unacceptable risk of infectious or neoplastic disease. To this end, immunotoxicity testing has employed a variety of host resistance challenge models for measuring both host resistance to disease as well as immune function. This chapter provides an overview of those viral, bacterial, fungal, and parasitic host resistance models that are most commonly used in safety assessment. It also describes in more detail the bacterial challenge models that are employed to address specific host resistance and immune function issues.
免疫毒性测试用于提供安全性评估，其主要目的是避免感染性疾病或肿瘤性疾病的不可接受风险。为此，免疫毒性测试采用了多种宿主抗性挑战模型来测量宿主对疾病的抗性以及免疫功能。本章概述了在安全性评估中最常用的病毒、细菌、真菌和寄生虫宿主抗性模型。它还更详细地描述了用于解决特定宿主抗性和免疫功能问题的细菌挑战模型。
