Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan.
Neuroradiology. 2010 Oct;52(10):913-20. doi: 10.1007/s00234-009-0634-4. Epub 2009 Dec 5.
Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to compare hemodynamics of intracranial aneurysms of MR fluid dynamics (MRFD) using 3D cine PC MR imaging (4D-Flow) at 1.5 T and MR-based computational fluid dynamics (CFD).
4D-Flow was performed for five intracranial aneurysms by a 1.5 T MR scanner. 3D TOF MR angiography was performed for geometric information. The blood flow in the aneurysms was modeled using CFD simulation based on the finite element method. We used MR angiographic data as the vascular models and MR flow information as boundary conditions in CFD. 3D velocity vector fields, 3D streamlines, shearing velocity maps, wall shear stress (WSS) distribution maps and oscillatory shear index (OSI) distribution maps were obtained by MRFD and CFD and were compared.
There was a moderate to high degree of correlation in 3D velocity vector fields and a low to moderate degree of correlation in WSS of aneurysms between MRFD and CFD using regression analysis. The patterns of 3D streamlines were similar between MRFD and CFD. The small and rotating shearing velocities and higher OSI were observed at the top of the spiral flow in the aneurysms. The pattern and location of shearing velocity in MRFD and CFD were similar. The location of high oscillatory shear index obtained by MRFD was near to that obtained by CFD.
MRFD and CFD of intracranial aneurysms correlated fairly well.
血液动力学被认为在颅内动脉瘤的发生、生长和破裂中起着非常重要的作用。我们的研究目的是比较使用 1.5T MR 电影相位对比磁共振成像（4D-Flow）和基于 MR 的计算流体动力学（CFD）对颅内动脉瘤的血液动力学。
使用 1.5T MR 扫描仪对五个颅内动脉瘤进行 4D-Flow 检查。进行三维时间飞跃磁共振血管造影以获取几何信息。使用基于有限元法的 CFD 模拟对动脉瘤内的血流进行建模。我们使用磁共振血管造影数据作为血管模型，并将 MR 流量信息作为 CFD 中的边界条件。通过 MRFD 和 CFD 获得了 3D 速度矢量场、3D 流线、剪切速度图、壁面剪切应力（WSS）分布图和振荡剪切指数（OSI）分布图，并进行了比较。
通过回归分析，在动脉瘤的 3D 速度矢量场中存在中度到高度的相关性，而在 WSS 中存在低度到中度的相关性。在 MRFD 和 CFD 中，3D 流线的模式相似。在动脉瘤的螺旋流顶部观察到小而旋转的剪切速度和较高的 OSI。MRFD 和 CFD 中剪切速度的模式和位置相似。MRFD 获得的高振荡剪切指数的位置接近 CFD 获得的位置。
颅内动脉瘤的 MRFD 和 CFD 相关性较好。
