Rodríguez-Prieto M A, Alonso-Alonso T, Toribio-García J A, Mateos-Hernández A
Hospital de León, León, España.
Arch Soc Esp Oftalmol. 2009 Nov;84(11):581-4. doi: 10.4321/s0365-66912009001100009.
We present the case of a 47-year-old female suffering from progeria who developed an eyelid Merkel cell carcinoma (MCC) following cyclosporine treatment for a corneal transplant. She underwent excision of the lesion by Mohs micrographic surgery (MMS) and received adjuvant treatment with radiotherapy. Later she had a recurrent tumour for which a wide excision with orbital exenteration was performed. The patient was fit and well at the 24-month follow-up.
MCC is an aggressive tumour that has a larger incidence in elderly people, women and immunosuppressed patients. Our approach with the patient must be global, avoiding risk factors in predisposed subjects. MMS seems unsuitable for the treatment of MCC; if tumour recurrence occurs a wide resection should be performed (Arch Soc Esp Oftalmol 2009; 84: 581-584).
我们报告一例47岁患有早衰症的女性病例，该患者在接受角膜移植的环孢素治疗后发生了眼睑默克尔细胞癌（MCC）。她通过莫氏显微外科手术（MMS）切除了病变，并接受了放射治疗作为辅助治疗。后来她出现了复发性肿瘤，为此进行了广泛切除并眼眶内容物剜除术。在24个月的随访中，患者身体状况良好。
MCC是一种侵袭性肿瘤，在老年人、女性和免疫抑制患者中发病率较高。我们对该患者的治疗方法必须全面，避免在易感人群中出现危险因素。MMS似乎不适用于MCC的治疗；如果发生肿瘤复发，应进行广泛切除（《西班牙眼科协会杂志》2009年；84：581 - 584）。
