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[肠道神经内分泌肿瘤。病例报告及文献综述]

[Intestinal neuroendocrine tumor. Case report and review of the literature].

作者信息

Micheletto Giancarlo, Sciannamea Ivano, Zanoni Adelinda, Panizzo Valerio, Rubino Barbara, Danelli Piergiorgio

机构信息

Università degli Studi di Milano.

出版信息

Ann Ital Chir. 2009 Jul-Aug;80(4):319-24.

Abstract

Gastroenteropancreatic (GEP) neuroendocrine tumors are rare neoplasm and have proved to be slow growing malignancies which involve many organs and most frequently the gastrointestinal tract. They have a peculiary biological behaviour: most of them have endocrine function (carcinoid syndrome); many are clinically silent until late presentation. Symptoms are non specific; the most common are abdominal pain, nausea and vomiting, weight loss and gastrointestinal (GI) blood loss. Incidental carcinoid, discovered at the time of another procedure, occurred in 40% of patients, and in multiple site throughout the GI tract. Here we report a case of a 73-year-old male with an adenomatous colonic polyp, not suitable of endoscopic treatment, and a synchronous carcinoid of small intestine discovered during surgical procedure. Therefore we performed a review of literature with particular attention to diagnosis and strategy of the treatment.

摘要

胃肠胰(GEP)神经内分泌肿瘤是罕见的肿瘤,已被证明是生长缓慢的恶性肿瘤,可累及多个器官,最常见于胃肠道。它们具有独特的生物学行为:大多数具有内分泌功能(类癌综合征);许多在晚期出现之前临床上无症状。症状不具特异性;最常见的是腹痛、恶心、呕吐、体重减轻和胃肠道失血。在另一次手术时偶然发现的类癌,在40%的患者中出现,且遍布胃肠道的多个部位。我们在此报告一例73岁男性患者,其患有不适合内镜治疗的结肠腺瘤性息肉,并在手术过程中发现了同步的小肠类癌。因此,我们对文献进行了回顾,特别关注诊断和治疗策略。

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