Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington, USA 99164-7040.
Onderstepoort J Vet Res. 2009 Mar;76(1):75-9. doi: 10.4102/ojvr.v76i1.68.
Sir Arnold Theiler's research in 1908/09 led to the discovery of the first rickettsial pathogen, Anaplasma marginale, and set the stage for his development and implementation of an effective live vaccine based on a less virulent strain, A. marginale ss. centrale. His 1910 report, describing A. marginale, is among the classic monographs in infectious disease research, presenting not only observations in exacting detail but also highlighting the deductive reasoning leading to association of a new pathogen with a specific disease. With a centennial perspective and both conceptual frameworks and molecular tools unimaginable in Theiler's time, the significance of several observations in the original report--cyclic bacteremia, strain superinfection, and taxonomic position--is now clear and highlight the broad applicability of key principles of pathogen biology.
阿诺德·泰勒爵士（Sir Arnold Theiler）于 1908/09 年开展的研究发现了第一种立克次体病原体——边缘无浆体（Anaplasma marginale），并为他研发和应用基于毒力较弱菌株（A. marginale ss. centrale）的有效活疫苗奠定了基础。他在 1910 年发表的报告描述了边缘无浆体，该报告是传染病研究的经典专著之一，不仅详细描述了观察结果，还突出了推理思维，将一种新病原体与特定疾病联系起来。从百年的视角来看，以及从当时无法想象的概念框架和分子工具来看，原始报告中的几个观察结果——周期性菌血症、菌株超感染和分类地位——现在已经很清楚，突出了病原体生物学关键原则的广泛适用性。
