Song Li, Chen Jia-Lin
Department of General Internal Medicine, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Oct;31(5):651-3.
Idiopathic myelofibrosis a Philadelphia-negative chronic myeloproliferative disorder. Potentially curative therapies, such as stem-cell transplantation, are reserved only for a minority of patients. Currently palliative therapies such as androgen and hydroxycarbamide are commonly used but with poor results. Thalidomide has anti-angiogenic effect and also can inhibit cytokines, and therefore plays a certain role in the treatment of a subset of idiopathic myelofibrosis.
原发性骨髓纤维化是一种费城染色体阴性的慢性骨髓增殖性疾病。潜在的治愈性疗法，如干细胞移植，仅适用于少数患者。目前常用的姑息性疗法，如雄激素和羟基脲，但效果不佳。沙利度胺具有抗血管生成作用，还能抑制细胞因子，因此在一部分原发性骨髓纤维化的治疗中发挥一定作用。
