Khanal S, Zhang W, Shrestha N Rajbhandari, Dahal G R
Department of Epidemiology, College of Public Health, Zhengzhou University, Henan, China.
Nepal Med Coll J. 2009 Jun;11(2):99-103.
The aim of the study was to find out the neonatal outcome of infants born with history of preterm premature rupture of membrane (PPROM) and to compare with infants born without history of PPROM. It was a retrospective study that included 187 preterm newborn with history of PPROM admitted in neonatal intensive care unit of the third affiliated hospital of Zhengzhou University from January 2008 to December 2008. Another 150 preterm newborns from same department during same period were taken as control. Patient demographics, patient's problem, investigation, management and outcome were recorded from medical record department and compared. Chi square and t test were used for statistical analysis. There was no statistical difference of gestational age, mode of delivery, birth weight and gender between case and control group. Respiratory system related problems like birth asphyxia, respiratory distress syndrome, apnea and pneumonia were common in both group but not statistical significant (p>0.05). However, need of oxygen supply and mechanical ventilation was significantly more (p<0.05) in case group. Neonatal death was more in case group (5.3%) than in control group (0.7%) and was statistically significant (p<0.001). The morbidity of preterm neonate does not entirely depend on history of PPROM than prematurity itself. However severity of disease and death is more with history of PPROM.
本研究的目的是了解有早产胎膜早破（PPROM）病史的婴儿的新生儿结局，并与无PPROM病史的婴儿进行比较。这是一项回顾性研究，纳入了2008年1月至2008年12月在郑州大学第三附属医院新生儿重症监护病房收治的187例有PPROM病史的早产新生儿。同期从同一科室选取另外150例早产新生儿作为对照。从病历科室记录患者的人口统计学资料、患者问题、检查、治疗及结局，并进行比较。采用卡方检验和t检验进行统计学分析。病例组和对照组在胎龄、分娩方式、出生体重和性别方面无统计学差异。两组中与呼吸系统相关的问题如出生窒息、呼吸窘迫综合征、呼吸暂停和肺炎均较为常见，但无统计学意义（p>0.05）。然而，病例组的氧气供应需求和机械通气需求显著更高（p<0.05）。病例组的新生儿死亡率（5.3%）高于对照组（0.7%），且具有统计学意义（p<0.001）。早产新生儿的发病率并不完全取决于PPROM病史，而更多地取决于早产本身。然而，有PPROM病史的患儿疾病严重程度和死亡率更高。
