Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.
Eur J Neurol. 2010 Mar;17(3):419-25. doi: 10.1111/j.1468-1331.2009.02861.x. Epub 2009 Nov 24.
Recent studies suggest that migraine is associated with metabolic disorders. In particular, migraine may be associated with cardiovascular risk; however, an association of migraine with cardiovascular risk factors like hypercholesterolemia has been proposed, but previous studies have yielded in part conflicting results. The aim of the present study is to evaluate the lipid profile in normal weight migraine patients.
One hundred thirty-six probands participated in this study. The study group was divided into normal weight migraineurs and control groups, including normal weight controls, obese and overweight controls and migraineurs. Various parameters of the lipid metabolism and inflammatory parameters were investigated.
We found significant increased cholesterol, low density lipoprotein cholesterol (LDL-C) and oxidized LDL-C in normal weight migraineurs. Increased oxidized LDL-C was associated with a 7.93-fold increased risk for migraine. Alterations in the lipid profile were not accompanied by increased inflammatory parameters.
We show here that normal weight migraineurs exhibit independent of aura symptoms an atherogenic lipid profile, which shares common features with obesity-related lipid alterations. Our data suggest that migraine is associated with a higher risk for cardiovascular disease and its clinical consequences.
最近的研究表明偏头痛与代谢紊乱有关。特别是，偏头痛可能与心血管风险相关；然而，已经提出偏头痛与高胆固醇血症等心血管危险因素相关，但以前的研究部分得出了相互矛盾的结果。本研究旨在评估正常体重偏头痛患者的血脂谱。
136 名患者参与了这项研究。研究组分为正常体重偏头痛患者和对照组，包括正常体重对照组、肥胖和超重对照组以及偏头痛患者。研究了脂质代谢和炎症参数的各种参数。
我们发现正常体重偏头痛患者的胆固醇、低密度脂蛋白胆固醇（LDL-C）和氧化 LDL-C 显著增加。氧化 LDL-C 的增加与偏头痛的风险增加 7.93 倍相关。脂质谱的改变没有伴随着炎症参数的增加。
我们在这里表明，正常体重偏头痛患者表现出与先兆症状无关的动脉粥样硬化脂质谱，这与肥胖相关的脂质改变具有共同特征。我们的数据表明偏头痛与心血管疾病及其临床后果的风险增加相关。
