20 至 34 孕周胎儿循环中 N-末端 pro-B 型利钠肽的参考值。
Reference values for N-terminal pro-B-type natriuretic peptide in fetal circulation between 20 and 34 weeks of gestation.
机构信息
Department of Obstetrics and Prenatal Medicine, University of Bonn Medical School, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.
出版信息
Clin Biochem. 2010 Mar;43(4-5):519-21. doi: 10.1016/j.clinbiochem.2009.11.012. Epub 2009 Dec 5.
OBJECTIVE
We aimed to investigate the range of fetal NT-proBNP values in normal pregnancy between 20 and 34 weeks of gestation.
METHOD
NT-proBNP was measured in 56 fetal blood samples.
RESULTS
Mean (+ or - 2 SD) NT-proBNP concentration was 1998 (242-3754) ng/L; a significant decline occurred with advancing gestational age (p=0.012).
CONCLUSIONS
Gestational age has to be taken in to consideration in the assessment of NT-proBNP. Our data may be used as reference values in fetal and neonatal medicine.
目的
本研究旨在探讨 20-34 孕周正常妊娠胎儿血 NT-proBNP 值的范围。
方法
对 56 例胎儿血 NT-proBNP 进行检测。
结果
平均（+或-2SD）NT-proBNP 浓度为 1998（242-3754）ng/L；随着孕周的增加，浓度显著下降（p=0.012）。
结论
在评估 NT-proBNP 时，必须考虑到孕周的影响。本研究数据可作为胎儿和新生儿医学的参考值。
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