系统性肉碱缺乏症的动物模型：与青少年内脏脂肪变性相关的C3H-H-2°品系小鼠的分析。
Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis.
作者信息
Kuwajima M, Kono N, Horiuchi M, Imamura Y, Ono A, Inui Y, Kawata S, Koizumi T, Hayakawa J, Saheki T
机构信息
Second Department of Internal Medicine, Osaka University Medical School, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Feb 14;174(3):1090-4. doi: 10.1016/0006-291x(91)91532-h.
We analyzed carnitine profiles in C3H-H-2 degrees strain of mouse associated with fatty liver, hyperammonemia and hypoglycemia (Koizumi et al., 1988). Carnitine levels in serum, liver and muscle of mouse with fatty liver were markedly decreased in comparison with those of control mouse (littermates without fatty liver). This is a useful animal model to analyze the role of carnitine in lipid, amino acid and carbohydrate metabolism.
我们分析了与脂肪肝、高氨血症和低血糖相关的C3H-H-2°品系小鼠的肉碱谱（小泉等人，1988年）。与对照小鼠（无脂肪肝的同窝小鼠）相比，患有脂肪肝的小鼠血清、肝脏和肌肉中的肉碱水平明显降低。这是一个用于分析肉碱在脂质、氨基酸和碳水化合物代谢中作用的有用动物模型。
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