与inv dup(15)和智力迟钝相关的复发性抗精神病药物恶性综合征。

Recurrent neuroleptic malignant syndrome associated with inv dup(15) and mental retardation.

作者信息

Lazarus A L, Moore K E, Spinner N B

机构信息

Temple University School of Medicine, Philadelphia, Pennsylvania.

出版信息

Clin Genet. 1991 Jan;39(1):65-7. doi: 10.1111/j.1399-0004.1991.tb02987.x.

DOI:10.1111/j.1399-0004.1991.tb02987.x

PMID:1997219

Abstract

Neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse reaction to neuroleptic drugs. Clinically, it resembles malignant hyperthermia, a pharmacogenetic disorder of anesthesiology. Inv dup(15) is a rare but underrecognized cause of mental retardation among institutionalized patients. NMS and inv dup(15) have not been previously reported together. Their association should encourage clinicians to search for genetic markers for NMS.

摘要

抗精神病药恶性综合征（NMS）是一种对抗精神病药物罕见但严重的不良反应。临床上，它类似于恶性高热，一种麻醉学的药物遗传学疾病。inv dup(15)是机构化患者中智力迟钝的一种罕见但未被充分认识的病因。NMS和inv dup(15)此前尚未被一起报道过。它们之间的关联应促使临床医生寻找NMS的遗传标记。