脲原体脲酶对小鼠的毒力。
Virulence of ureaplasmal urease for mice.
作者信息
Ligon J V, Kenny G E
机构信息
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
出版信息
Infect Immun. 1991 Mar;59(3):1170-1. doi: 10.1128/iai.59.3.1170-1171.1991.
Abstract
Ureaplasmas killed mice within 5 min after intravenous injection. The 50% lethal dose of whole ureaplasmal organisms was 32 micrograms per mouse, a value also found for crystalline jackbean urease. The reaction was specific to urease, since protection was afforded by intraperitoneal injection of 200 micrograms of flurofamide, a potent urease inhibitor. The finding that a similar lethal effect was produced by injection of 200 mumol of NH4+ indicates that the toxicity of urease is mediated by ammonium ions or free ammonia.
摘要
脲原体在静脉注射后5分钟内可致小鼠死亡。全脲原体生物的半数致死剂量为每只小鼠32微克，该数值与结晶刀豆脲酶的半数致死剂量相同。该反应对脲酶具有特异性，因为腹腔注射200微克氟乙酰胺（一种有效的脲酶抑制剂）可起到保护作用。注射200微摩尔铵离子会产生类似的致死效应，这一发现表明脲酶的毒性是由铵离子或游离氨介导的。
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