Rottenberg D A, Moeller J R, Strother S C, Dhawan V, Sergi M L
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York.
J Cereb Blood Flow Metab. 1991 Mar;11(2):A83-8. doi: 10.1038/jcbfm.1991.42.
Although we and others have employed a thresholding strategy to extract "peak" values from positron emission tomographic (PET) regions of interest (ROIs), the effects of peak picking on fitted fluorodeoxyglucose rate constants, regional metabolic rate for glucose (rCMRglc) profiles, patterns of regional metabolic covariation, and PET-neurobehavioral correlations have not been systematically investigated. Our results suggest that under some commonly encountered imaging conditions percent thresholding may increase sensitivity to regional activation; however, the effect of thresholding is determined by a number of factors, including the relative magnitude of regional activation, ROI size, and the specific threshold selected. The difference-annulus concept is proposed as a means to study the effects of different region drawing and thresholding strategies, and to determine if a given ROI contains one and only one source of covarying metabolic activity.
尽管我们和其他人已经采用了一种阈值化策略，从正电子发射断层扫描（PET）感兴趣区域（ROI）中提取“峰值”值，但尚未系统地研究峰值提取对拟合的氟脱氧葡萄糖速率常数、区域葡萄糖代谢率（rCMRglc）曲线、区域代谢协变模式以及PET与神经行为相关性的影响。我们的结果表明，在一些常见的成像条件下，百分比阈值化可能会提高对区域激活的敏感性；然而，阈值化的效果取决于许多因素，包括区域激活的相对大小、ROI大小以及所选的特定阈值。提出了差异环概念，作为一种研究不同区域绘制和阈值化策略的影响，并确定给定ROI是否包含一个且仅一个协变代谢活动源的方法。
