Crumrine R C, LaManna J C
Department of Neurology, University Hospitals of Cleveland, Ohio 44106.
J Cereb Blood Flow Metab. 1991 Mar;11(2):272-82. doi: 10.1038/jcbfm.1991.59.
Cerebral high-energy metabolites and metabolic end products were measured during and following total cerebral ischemia in the rat. During cerebral ischemia, lactate accumulation was greatest in the hippocampus, followed by the cerebral cortex and striatum. Following reperfusion, the rate of lactate clearance was slower in the hippocampus than in the other two regions. Regional CBF, cerebral plasma volume (CPV), and calculated mean transit time (MTT) were determined following reflow of ischemic tissue. During hyperemia, CPV, used as an indicator of capillary volume, increased concomitantly with CBF while the MTT remained near the control value, suggesting that the linear flow rate through the vasculature was unchanged. During hypoperfusion, CPV returned to control values, but there was a significant increase in MTT that would result from a decreased linear velocity. The finding of normal tissue energy charge, pHi, and concentration of other metabolites during hypoperfusion shows that hypoperfusion does not result in CBF-metabolic mismatch.
在大鼠全脑缺血期间及之后，对脑高能代谢物和代谢终产物进行了测量。在脑缺血期间，乳酸积累在海马体中最为显著，其次是大脑皮层和纹状体。再灌注后，海马体中乳酸清除率比其他两个区域慢。在缺血组织再灌注后，测定了局部脑血流量（CBF）、脑血浆容量（CPV）和计算得出的平均通过时间（MTT）。在充血期间，用作毛细血管容量指标的CPV与CBF同时增加，而MTT保持在接近对照值的水平，这表明通过血管系统的线性流速未发生变化。在灌注不足期间，CPV恢复到对照值，但MTT显著增加，这是由线性速度降低导致的。灌注不足期间组织能量电荷、细胞内pH值（pHi）和其他代谢物浓度正常这一发现表明，灌注不足不会导致CBF与代谢不匹配。
