Marion D W, Crosby K
Division of Neurological Surgery, Medical College of Virginia, Richmond 23298.
J Cereb Blood Flow Metab. 1991 Mar;11(2):347-50. doi: 10.1038/jcbfm.1991.69.
Recent studies have suggested that under certain conditions, inhalation of stable xenon can cause an increase in CBF or intracranial pressure (ICP). We reviewed the ICP changes that occurred during 48 stable xenon/CT CBF studies in 23 comatose head-injured patients to determine if the concentration (32%) and duration of inhalation (4.5 min) of stable xenon we used caused an increase in ICP. In the group as a whole, there was no significant difference between the mean ICP at the start of xenon inhalation and the mean ICP immediately after completion of the studies. An increase in ICP also was not found in subgroups with low, normal, or high global CBF, or groups with or without intracranial hypertension. Changes in ICP that occurred during individual studies usually were related to corresponding changes in the arterial pCO2 (p less than 0.0001, Pearson's correlation test). Our data suggest that 32% stable xenon administered for 4.5 min does not cause a significant increase in ICP during xenon/CT CBF studies.
最近的研究表明，在某些情况下，吸入稳定的氙气可导致脑血流量（CBF）增加或颅内压（ICP）升高。我们回顾了23例昏迷性头部受伤患者在48次稳定氙气/CT脑血流量研究期间发生的颅内压变化，以确定我们使用的稳定氙气浓度（32%）和吸入持续时间（4.5分钟）是否会导致颅内压升高。在整个研究组中，氙气吸入开始时的平均颅内压与研究完成后立即测得的平均颅内压之间没有显著差异。在全脑血流量低、正常或高的亚组中，以及有或没有颅内高压的组中，也未发现颅内压升高。在个别研究中发生的颅内压变化通常与动脉血二氧化碳分压的相应变化有关（p<0.0001，Pearson相关检验）。我们的数据表明，在氙气/CT脑血流量研究期间，给予32%的稳定氙气4.5分钟不会导致颅内压显著升高。
