Kaver I, Koontz W W, Wilson J D, Guice J M, Ware J L
Division of Urology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
J Urol. 1991 Mar;145(3):654-6. doi: 10.1016/s0022-5347(17)38414-8.
The effect of radiation and/or hyperthermia on a human prostatic carcinoma xenograft in athymic nude mice was investigated. A human prostate carcinoma subline (1-LN-PC-3-1A) was inoculated subcutaneously in the thigh of male athymic nude mice. When tumors reached a size of approximately 200 mm.3, they were treated with either radiation (X) or hyperthermia (H) alone, or in combination (X + H). In the combined treatment, hyperthermia was delivered immediately after radiation exposure. Comparison of the time required to reach twice the tumor volume observed at the time of treatment was used to define therapeutic impact on tumor growth. The combined treatment resulted in median tumor volume doubling time of 35.5 days, compared to 18 days and 25.5 days, respectively, for hyperthermia or radiation alone. Analysis of tumor doubling time using a proportional hazards regression indicates that under the conditions of this experiment, the effect of radiation and hyperthermia for 1-LN-PC-3-1A tumors is additive. The impact of this treatment regimen in the management of prostatic cancer requires further investigation.
研究了辐射和/或热疗对无胸腺裸鼠体内人前列腺癌异种移植瘤的影响。将人前列腺癌亚系（1-LN-PC-3-1A）皮下接种于雄性无胸腺裸鼠的大腿。当肿瘤大小达到约200立方毫米时，分别单独用辐射（X）或热疗（H），或联合使用（X + H）进行治疗。在联合治疗中，热疗在辐射暴露后立即进行。通过比较达到治疗时观察到的肿瘤体积两倍所需的时间来确定对肿瘤生长的治疗效果。联合治疗导致肿瘤体积中位数加倍时间为35.5天，而单独热疗或辐射分别为18天和25.5天。使用比例风险回归分析肿瘤加倍时间表明，在本实验条件下，辐射和热疗对1-LN-PC-3-1A肿瘤的作用是相加的。这种治疗方案在前列腺癌管理中的影响需要进一步研究。
