3,3-二甲基-1-苯基三氮烯的致畸性：在大鼠及大鼠胚胎中的分布

Teratogenicity of 3,3-dimethyl-1-phenyltriazene: distribution in rats and rat embryos.

作者信息

Frank A A, Kazacos E A, Thompson D J

机构信息

Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN.

出版信息

Toxicol Lett. 1991 Jan;55(1):55-64. doi: 10.1016/0378-4274(91)90027-4.

DOI:10.1016/0378-4274(91)90027-4

PMID:1998197

Abstract

3,3-Dimethyl-1-phenyltriazene (DMPT) is a methylating agent which is carcinogenic, teratogenic and mutagenic which, in the rat, provides a reproducible animal model with which to study the basis of chemically-induced micrognathism. The basis of teratogenic organotropism of DMPT and other methylating teratogens is unknown. The present study was undertaken to determine if limited chemical distribution within the embryo was responsible for the organotropism of DMPT. Whole-embryo autoradiographs and liquid scintillation analysis indicated that although DMPT may have some limitations of chemical distribution within the embryo, these limitations are not sufficient to explain its teratogenic organotropism.

摘要

3,3-二甲基-1-苯基三氮烯（DMPT）是一种甲基化剂，具有致癌、致畸和致突变性，在大鼠中可提供一个可重复的动物模型，用于研究化学诱导小颌畸形的基础。DMPT和其他甲基化致畸剂的致畸器官特异性基础尚不清楚。本研究旨在确定胚胎内有限的化学物质分布是否是DMPT器官特异性的原因。全胚胎放射自显影片和液体闪烁分析表明，尽管DMPT在胚胎内的化学物质分布可能存在一些限制，但这些限制不足以解释其致畸器官特异性。