分子量为48,000的核抗原与恶性转化相关。

Nuclear antigen with a molecular weight of 48,000 associated with malignant transformation.

Krajewska W M, Marszałek M, Gaczyński M, Kłyszejko-Stefanowicz L

Department of Cytobiochemistry, University of Lodz, Poland.

Int J Biochem. 1991;23(2):195-201. doi: 10.1016/0020-711x(91)90189-t.

Abstract

Analysis of immunoblots of one- and two-dimensional electropherograms of non-histone proteins from Kirkman-Robbins hepatoma, Morris hepatoma 7777, regenerating liver and normal liver demonstrated the presence of elevated level of nuclear antigen with mol. wt of 48,000 and pI of 5.4 in tumour cells. 2. Small amounts only were detected in proliferating and quiescent cells suggesting that different expression of this component may reflect biochemical events related to malignant transformation rather than to general cell activation.

摘要

对柯克曼 - 罗宾斯肝癌、莫里斯肝癌7777、再生肝和正常肝中非组蛋白的一维及二维电泳图谱进行免疫印迹分析，结果显示肿瘤细胞中存在分子量为48,000、等电点为5.4的核抗原水平升高的情况。2. 在增殖细胞和静止细胞中仅检测到少量该抗原，这表明该成分的不同表达可能反映了与恶性转化相关的生化事件，而非一般的细胞激活。