Department of Anesthesiology and Intensive Care Unit, Changhai Hospital, Second Military Medical University, Shanghai, China.
Anaesthesia. 2010 Feb;65(2):158-62. doi: 10.1111/j.1365-2044.2009.06186.x. Epub 2009 Nov 25.
Nuclear factor (NF)-kappaB (NFKB1)-94ins/del is an important polymorphism that affects promoter activity of the NFKB1 gene and is potentially associated with several inflammatory diseases. We investigated the association of this polymorphism with lung injury after cardiac surgery and cardiopulmonary bypass in a prospective cohort study of 283 patients. Genotyping was performed by high resolution melting analysis; analysis indicated no association of NFKB1 with postoperative lung injury (p = 0.064). Relative risks of the del allele and the del/del genotype were 1.34 (95% CI 1.02-1.75) and 1.74 (95% CI 1.00-3.05) respectively. Logistic regression analysis (with factors including age, peripheral vascular disease and surgical duration as risk factors of lung injury after cardiac surgery with cardiopulmonary bypass) also failed to confirm that the NFKB1 genotype is influential for lung injury (p = 0.113). We conclude that, contrary to some other evidence, the NFKB1-94ins/del polymorphism is not associated with lung injury after cardiac surgery with cardiopulmonary bypass.
核因子（NF）-κB（NFKB1）-94ins/del 是一种重要的多态性，它影响 NFKB1 基因的启动子活性，并可能与多种炎症性疾病有关。我们在 283 例患者的前瞻性队列研究中，研究了这种多态性与心脏手术后心肺旁路引起的肺损伤之间的关系。通过高分辨率熔解分析进行基因分型；分析表明，NFKB1 与术后肺损伤无关（p = 0.064）。del 等位基因和 del/del 基因型的相对风险分别为 1.34（95%CI 1.02-1.75）和 1.74（95%CI 1.00-3.05）。逻辑回归分析（将年龄、外周血管疾病和手术时间等因素作为心肺旁路心脏手术后肺损伤的危险因素）也未能证实 NFKB1 基因型对肺损伤有影响（p = 0.113）。我们的结论是，与其他一些证据相反，NFKB1-94ins/del 多态性与心肺旁路心脏手术后的肺损伤无关。
