Guiglia M C, Prendiville J S
Division of Dermatology, Children's Medical Center, Dayton, OH.
J Am Acad Dermatol. 1991 Feb;24(2 Pt 2):359-63. doi: 10.1016/0190-9622(91)70052-4.
We describe an 11-year-old girl in whom multiple cutaneous granular cell tumors were associated with a giant speckled lentiginous nevus and an extensive nevus flammeus. An association between granular cell tumors and pigmented skin lesions has been reported twice previously and supports a neural origin for these tumors. An abnormality of neural crest development is proposed to explain the coexistence of three uncommon and unusually extensive cutaneous disorders in this patient. This case may represent a further variant of phakomatosis pigmentovascularis.
我们描述了一名11岁女孩，其多发性皮肤颗粒细胞瘤与巨大斑点状先天性黑素细胞痣及广泛的火焰状痣相关。颗粒细胞瘤与色素沉着性皮肤病变之间的关联此前已有两次报道，这支持了这些肿瘤的神经起源。有人提出神经嵴发育异常来解释该患者三种罕见且异常广泛的皮肤疾病共存的现象。该病例可能代表了色素血管性斑痣性错构瘤病的又一变种。
