Rakotoson J L, Randriamanana D, Rakotomizao J R, Andrianasolo R, Rakotoarivelo R, Andrianarisoa A C F
Unité de soins, de formations et de recherches de pneumologie, CHU d'Antananarivo, Antananarivo, Madagascar.
Rev Pneumol Clin. 2009 Dec;65(6):361-4. doi: 10.1016/j.pneumo.2009.08.006. Epub 2009 Oct 30.
The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native DNA, anti-ENA, anti-Sm, anti-SSa, anti-SSb and antihistone were present. The symptoms included arthralgia, fever, anaemia, pleural effusion, pericarditis and anasarca. She presented a renal and neurological attack, accounting for the gravity of the disease. The treatment consisted of the interruption of the isoniazid and a bolus of methyl-prednisolone during 3 days relayed by an oral corticosteroid. The evolution was favourable after 8 months of corticosteroids.
作者报告了一例罕见的低活动性系统性红斑狼疮病例，该病例因异烟肼引发肾脏损害和神经损害。患者为一名23岁女性，在接受胸膜结核治疗1个月后出现异烟肼诱发的狼疮。存在抗核抗体、抗天然DNA、抗可提取性核抗原（ENA）、抗Sm、抗SSa、抗SSb和抗组蛋白抗体。症状包括关节痛、发热、贫血、胸腔积液、心包炎和全身性水肿。她出现了肾脏和神经损害，这说明了该疾病的严重性。治疗包括停用异烟肼，并静脉注射甲基泼尼松龙3天，之后改为口服皮质类固醇。使用皮质类固醇8个月后病情好转。
