Department of Cardiology and Angiology, University Hospital Freiburg, Hugstetterstrasse 55, Freiburg, Germany.
Circ Cardiovasc Imaging. 2010 Jan;3(1):54-64. doi: 10.1161/CIRCIMAGING.108.813857. Epub 2009 Dec 8.
An exact understanding of normal age- and gender-matched regional myocardial performance is an essential prerequisite for the diagnosis of heart disease. Magnetic resonance phase-contrast imaging (tissue phase mapping) enabling the analysis of segmental, 3-directional myocardial velocities with high temporal resolution (13.8 ms) was used to assess left ventricular motion.
Radial, long-axis, and rotational myocardial velocities were acquired in 58 healthy volunteers (3 age groups, 29 women) in left ventricular basal, midventricular, and apical short-axis locations. For increased age, reduced (P<0.003) and prolonged long-axis and radial velocities (P<0.05) during diastole and reduced long-axis velocities (P<0.001) and apical rotation (P<0.005) during systole were found for both genders. Women demonstrated a reduced systolic twist (P=0.009), apical rotation (P=0.01), and systolic radial velocities (P<0.02) compared with men. Segmental analysis of long-axis motion with aging revealed differences in regional reduction of systolic (lateral 52% versus 30%) and diastolic (lateral 57% versus 41%) velocities in women compared with men. In basal segments, young women demonstrated higher long-axis velocities (+11% during diastole) than men, whereas this difference was reversed in older subjects (same segments, -20%). In addition, increased age resulted in a prolonged time to peak diastolic apical rotation (P<0.04) in women compared with men.
Age and gender strongly influence regional myocardial motion. Tissue phase mapping provides a comprehensive quantitative analysis of all myocardial velocities with high temporal and spatial resolution. The knowledge of the detected age- and gender-related differences in myocardial motion is fundamental for further investigations of cardiac disease. Clinical Trial Registration- http://www.zks.uni-freiburg.de/uklreg/php/suchergebnis_all.php. Identifier: UKF001739.
准确了解正常年龄和性别匹配的区域性心肌功能是诊断心脏病的必要前提。磁共振相位对比成像（组织相位映射）可实现节段性、三维心肌速度的高时间分辨率（13.8ms）分析，用于评估左心室运动。
在 58 名健康志愿者（3 个年龄组，29 名女性）的左心室基底、中间心室和心尖短轴位置采集径向、长轴和旋转心肌速度。随着年龄的增长，男女舒张期的长轴和径向速度降低（P<0.003）且时间延长（P<0.05），收缩期的长轴速度降低（P<0.001），心尖旋转速度降低（P<0.005）。与男性相比，女性的收缩期扭转（P=0.009）、心尖旋转（P=0.01）和收缩期径向速度（P<0.02）降低。随着年龄的增长，长轴运动的节段分析显示，女性的收缩期（外侧 52%比 30%）和舒张期（外侧 57%比 41%）速度的区域性降低与男性不同。在基底节段，年轻女性的长轴速度比男性高（舒张期增加 11%），而在老年患者中则相反（同一节段，减少 20%）。此外，与男性相比，女性的峰值舒张期心尖旋转时间延长（P<0.04）。
年龄和性别强烈影响区域性心肌运动。组织相位映射可提供高时间和空间分辨率的所有心肌速度的全面定量分析。了解心肌运动中检测到的年龄和性别相关差异是进一步研究心脏病的基础。临床试验注册-http://www.zks.uni-freiburg.de/uklreg/php/suchergebnis_all.php。标识符：UKF001739。
Zotero 插件