Nikitin Nikolay P, Loh Poay Huan, de Silva Ramesh, Witte Klaus K A, Lukaschuk Elena I, Parker Anita, Farnsworth T Alan, Alamgir Farqad M, Clark Andrew L, Cleland John G F
Academic Department of Cardiology, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston-upon-Hull, HU16 5JQ United Kingdom.
Int J Cardiol. 2006 Mar 22;108(1):76-83. doi: 10.1016/j.ijcard.2005.04.009.
The heart transforms structurally and functionally with age but the nature and magnitude of reported changes appear inconsistent. This study was designed to assess left ventricular (LV) morphology, global and longitudinal function in healthy older men and women using cardiac magnetic resonance (CMR).
Ninety-five healthy subjects (age 62+/-16 years, range 22-91 years) underwent breath-hold cine CMR. LV end-diastolic volume (EDV), end-systolic volume (ESV), myocardial mass, ejection fraction (EF), mass-to-volume ratio, mean midventricular wall motion, thickness and thickening were calculated from short-axis data sets. Average mitral annular displacement was measured to assess longitudinal LV function.
Subjects were divided according to age (< 65 and > or = 65 years) and sex. EDV and ESV indices (corrected for body surface area) decreased whilst EF increased with age. There was no difference in LV myocardial mass index between the age groups, but midventricular wall thickness was significantly higher in older people. Mass-to-volume ratio also increased with age. In contrast to EF, mitral annular displacement declined with age. Midventricular LV wall thickness, myocardial mass index and mass-to-volume ratio were higher in men than in women but there were no differences in measures of global and longitudinal LV systolic function.
Due to smaller LV volumes but higher wall thickness, myocardial mass remains unchanged with age. We have found an age-related increase in EF and reduction in longitudinal LV function in apparently normal subjects. This must be borne in mind when assessing older patients with possible heart failure and normal LV systolic function. Men have higher myocardial mass than women.
心脏的结构和功能会随着年龄增长而发生变化，但已报道的变化的性质和程度似乎并不一致。本研究旨在使用心脏磁共振成像（CMR）评估健康老年男性和女性的左心室（LV）形态、整体和纵向功能。
95名健康受试者（年龄62±16岁，范围22 - 91岁）接受屏气电影CMR检查。从短轴数据集计算左心室舒张末期容积（EDV）、收缩末期容积（ESV）、心肌质量、射血分数（EF）、质量与容积比、平均心室壁中部运动、厚度和增厚情况。测量平均二尖瓣环位移以评估左心室纵向功能。
受试者按年龄（<65岁和≥65岁）和性别进行分组。EDV和ESV指数（校正体表面积后）随年龄增长而降低，而EF随年龄增长而增加。年龄组之间左心室心肌质量指数无差异，但老年人的心室壁中部厚度显著更高。质量与容积比也随年龄增长而增加。与EF相反，二尖瓣环位移随年龄增长而下降。男性的心室壁中部厚度、心肌质量指数和质量与容积比高于女性，但左心室整体和纵向收缩功能的测量指标无差异。
由于左心室容积较小但壁厚度较高，心肌质量随年龄增长保持不变。我们发现在明显正常的受试者中，EF随年龄增长而增加，左心室纵向功能降低。在评估可能患有心力衰竭且左心室收缩功能正常的老年患者时，必须牢记这一点。男性的心肌质量高于女性。
