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刚果民主共和国金沙萨成年人口的季节性血细胞比容变化及健康风险

Seasonal hematocrit variation and health risks in the adult population of Kinshasa, Democratic Republic of Congo.

作者信息

Hightower C Makena, Hightower Joyce D, Vázquez Beatriz Y Salazar, Intaglietta Marcos

机构信息

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA.

出版信息

Vasc Health Risk Manag. 2009;5:1001-5. doi: 10.2147/vhrm.s8136. Epub 2009 Nov 23.

Abstract

Hematocrit (Hct) as an indicator of blood viscosity and mean arterial blood pressure (MAP) were assessed according to the season in adult participants of health screenings conducted throughout Kinshasa, Democratic Republic of Congo. Data was collected at the end of summer (April) and the end of winter (August) and identified by gender. Male Hcts in August were significantly higher (P < 0.0001) than in April (48.3% +/- 4.2% and 45.7% +/- 2.3%, respectively) while male MAP (85.0 +/- 8.4 mm Hg) was identical to that recorded in April (85.4 +/- 7.7 mm Hg). August female Hcts (41.4% +/- 3.1%) were statistically higher than those recorded in April (39.6% +/- 1.9%, P = 0.001), MAP being 82.3 +/- 7.3 vs 87.9 +/- 6.6 mm Hg, respectively (P = 0.0001). Systolic and diastolic blood pressures, heart rate, body mass indices, ages, and personal and familial medical histories of the August and April groups were not significantly different. This study offers further support for the assertion that the relationship between blood viscosity and pressure of a healthy population shows that increased Hct, and therefore increased blood viscosity is associated with lowered MAP, and presumably peripheral vascular resistance.

摘要

在刚果民主共和国金沙萨进行的成年健康筛查参与者中,根据季节评估了作为血液粘度指标的血细胞比容(Hct)和平均动脉血压(MAP)。在夏季末(4月)和冬季末(8月)收集数据,并按性别进行识别。8月男性的Hct显著高于4月(分别为48.3%±4.2%和45.7%±2.3%,P<0.0001),而男性MAP(85.0±8.4mmHg)与4月记录的MAP(85.4±7.7mmHg)相同。8月女性的Hct(41.4%±3.1%)在统计学上高于4月记录的Hct(39.6%±1.9%,P=0.001),MAP分别为82.3±7.3mmHg和87.9±6.6mmHg(P=0.0001)。8月组和4月组的收缩压、舒张压、心率、体重指数、年龄以及个人和家族病史无显著差异。这项研究进一步支持了以下观点:健康人群的血液粘度与血压之间的关系表明,Hct升高,进而血液粘度增加与MAP降低以及可能的外周血管阻力降低有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec5/2788592/6180b29abec1/vhrm-5-1001f1.jpg

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