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建立并鉴定雄激素非依赖性人前列腺癌细胞系 PcBra1、PcBra2 和 PcBra3。

Establishment and characterization of androgen-independent human prostate cancer cell lines, PcBra1, PcBra2, and PcBra3.

机构信息

Laboratory of Medical Investigation, Urology Department-LIM55, Medical School, São Paulo University, Av. Dr. Arnaldo 455, Room 2145, 01246-903, São Paulo, Brazil.

出版信息

In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):123-30. doi: 10.1007/s11626-009-9249-7. Epub 2009 Dec 8.

Abstract

One of the main obstacles for understanding biological events involved in cancer is the lack of experimental models for in vitro studies especially for prostate cancer (PC). There are a limited number of PC cell lines being the majority originated from metastatic tumors mostly acquired from American Tissue Cell Culture which demands importation an expensive and bureaucratic process. Also it is well known that there are ethnic differences between populations concerning the behavior of tumors and the research based on cell lines derived from Brazilians should be interesting. Our aim was to develop tumor cell lines from primary PC.

摘要

理解癌症相关生物事件的主要障碍之一是缺乏体外研究的实验模型,特别是前列腺癌(PC)。目前只有少数 PC 细胞系,且大多数都源自转移性肿瘤,主要来源于美国组织细胞培养物库,这需要昂贵且繁琐的进口程序。此外,众所周知,不同人群的肿瘤行为存在种族差异,因此基于源自巴西人的细胞系进行的研究应该是有趣的。我们的目标是从原发性 PC 中开发肿瘤细胞系。

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