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本文引用的文献

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Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells.Wnt信号通路对前列腺癌细胞中人类雄激素受体表达的复杂调控
Oncogene. 2006 Jun 8;25(24):3436-44. doi: 10.1038/sj.onc.1209366. Epub 2006 Feb 13.
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A human- and male-specific protocadherin that acts through the wnt signaling pathway to induce neuroendocrine transdifferentiation of prostate cancer cells.一种通过Wnt信号通路发挥作用以诱导前列腺癌细胞神经内分泌转分化的人类及男性特异性原钙黏蛋白。
Cancer Res. 2005 Jun 15;65(12):5263-71. doi: 10.1158/0008-5472.CAN-05-0162.
3
Effects of WNT/beta-catenin pathway activation on signaling through T-cell factor and androgen receptor in prostate cancer cell lines.WNT/β-连环蛋白信号通路激活对前列腺癌细胞系中T细胞因子和雄激素受体信号传导的影响
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Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications.晚期转移性前列腺癌患者中Wnt-1和β-连环蛋白表达上调：潜在的发病机制及预后意义
Cancer. 2004 Sep 15;101(6):1345-56. doi: 10.1002/cncr.20518.
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NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice.NE-10神经内分泌癌促进去势小鼠体内LNCaP异种移植瘤的生长。
Cancer Res. 2004 Aug 1;64(15):5489-95. doi: 10.1158/0008-5472.CAN-03-3117.
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Neuroendocrine cell differentiation in the CWR22 human prostate cancer xenograft: association with tumor cell proliferation prior to recurrence.CWR22人前列腺癌异种移植模型中的神经内分泌细胞分化：与复发前肿瘤细胞增殖的关联
Prostate. 2004 Jul 1;60(2):91-7. doi: 10.1002/pros.20032.
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Molecular determinants of resistance to antiandrogen therapy.抗雄激素治疗耐药性的分子决定因素。
Nat Med. 2004 Jan;10(1):33-9. doi: 10.1038/nm972. Epub 2003 Dec 21.
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Stem cells of the skin epithelium.皮肤上皮干细胞。
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Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration.Wnt信号通路在肌肉再生过程中诱导驻留的CD45+成体干细胞向肌源性分化。
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Beta-catenin-related anomalies in apoptosis-resistant and hormone-refractory prostate cancer cells.抗凋亡和激素难治性前列腺癌细胞中与β-连环蛋白相关的异常情况。
Clin Cancer Res. 2003 May;9(5):1801-7.

原钙黏蛋白-PC促进雄激素非依赖性前列腺癌细胞生长。

Protocadherin-PC promotes androgen-independent prostate cancer cell growth.

作者信息

Terry Stephane, Queires Luis, Gil-Diez-de-Medina Sixtina, Chen Min-Wei, de la Taille Alexandre, Allory Yves, Tran Phuong-Lan, Abbou Claude C, Buttyan Ralph, Vacherot Francis

机构信息

Department of Urology and Pathology of CHU Henri Mondor, INSERM E 03-37, Université Paris XII, Centre de Recherches Chirurgicales, Assistance Publique des Hôpitaux de Paris, Créteil, France.

出版信息

Prostate. 2006 Jul 1;66(10):1100-13. doi: 10.1002/pros.20446.

DOI:10.1002/pros.20446
PMID:16637074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2660890/
Abstract

BACKGROUND

Protocadherin-PC (PCDH-PC) expression is upregulated in apoptosis-resistant sublines of the LNCaP human prostate cancer (CaP) cell line. Here, we assess the role of PCDH-PC in CaP cells and its mRNA expression in human prostate tissues.

METHODS

LNCaP cells transfected with PCDH-PC were tested for their ability to grow in vitro and in vivo in androgen-deprived conditions. PCDH-PC mRNA expression was evaluated by semi-quantitative RT-PCR and by in situ hybridization.

RESULTS

PCDH-PC expression induced Wnt signaling in CaP cells and permitted androgen-independent growth of hormone-sensitive CaP cells. Expression of PCDH-PC-homologous transcripts was low and restricted to some epithelial cells in normal tissue and to CaP cells in tumors. However, hormone-resistant CaP cells expressed significantly higher levels of PCDH-PC-related mRNA.

CONCLUSIONS

Our findings suggest a novel mechanism for the progression of CaP involving expression of PCDH-PC. This novel protocadherin induces Wnt signaling, promotes malignant behavior and hormone-resistance of CaP cells.

摘要

背景

原钙黏蛋白-PC（PCDH-PC）在LNCaP人前列腺癌细胞系的抗凋亡亚系中表达上调。在此，我们评估PCDH-PC在前列腺癌细胞中的作用及其在人前列腺组织中的mRNA表达。

方法

检测转染PCDH-PC的LNCaP细胞在雄激素剥夺条件下的体外和体内生长能力。通过半定量RT-PCR和原位杂交评估PCDH-PC mRNA表达。

结果

PCDH-PC表达在前列腺癌细胞中诱导Wnt信号，并使激素敏感的前列腺癌细胞实现雄激素非依赖性生长。PCDH-PC同源转录本在正常组织中的表达较低，局限于一些上皮细胞，在肿瘤中则局限于前列腺癌细胞。然而，激素抵抗性前列腺癌细胞表达的PCDH-PC相关mRNA水平显著更高。

结论

我们的研究结果提示了一种涉及PCDH-PC表达的前列腺癌进展新机制。这种新型原钙黏蛋白诱导Wnt信号，促进前列腺癌细胞的恶性行为和激素抵抗。