Hu Yong-Liang, Zhu Jian-Hua, Jing Hua-Lan
The Third Department of Medicine, Wannan Medical College, Wuhu, China.
Fa Yi Xue Za Zhi. 2009 Oct;25(5):332-3.
To analyze the changes of the serum TNFalpha level in cadavers of drug anaphylactic shock(DAS) and to explore the significance of the TNFalpha testing in evaluation of death caused by DAS.
The level of serum TNFalpha from cardiac blood was determined by double antibody-sandwich ELISA method.
The level of TNFalpha in the experimental group was (131.6+/-9.4) pg/mL, while the level in the infectious diseases control group and the normal control group were (87.3+/-6.4) pg/mL and (17.2+/-4.5) pg/mL, respectively. There was statistically significant difference among the groups (P<0.05).
The serum TNFalpha level may be used as one of the indexes for evaluation of death caused by highly suspected drug anaphylactic shock.
分析药物过敏性休克（DAS）死亡尸体血清肿瘤坏死因子α（TNFα）水平变化，探讨TNFα检测在评估DAS致死中的意义。
采用双抗体夹心ELISA法检测心血中血清TNFα水平。
实验组TNFα水平为（131.6±9.4）pg/mL，传染病对照组和正常对照组分别为（87.3±6.4）pg/mL和（17.2±4.5）pg/mL。组间差异有统计学意义（P<0.05）。
血清TNFα水平可作为评估高度怀疑药物过敏性休克致死的指标之一。
