Tufts University School of Medicine, Boston, Massachusetts, USA.
Am J Clin Dermatol. 2010;11(1):21-33. doi: 10.2165/11310380-000000000-00000.
Forty-seven cases of juvenile pemphigus vulgaris have been reported in the English literature. Histology of lesional skin and direct immunofluorescence of perilesional skin are both necessary for a complete diagnosis. The autoimmune bullous condition can affect the skin and mucous membranes individually, but typically affects both concurrently. Disease characteristics in juvenile patients are similar to those in adults; however, a disruption of biologic and social development is of particular concern during adolescence. Although systemic corticosteroids have been used to successfully treat the disease in most cases, long-term use is often necessary for adequate control. Adverse effects from therapy can have devastating effects during this critical period of hormonal changes, physical and mental growth, and social and cultural development that occurs during adolescence. Newer therapies must be designed to adequately treat juvenile patients while also limiting serious adverse effects.
英文文献中报道了 47 例青少年寻常型天疱疮。皮损皮肤的组织病理学和皮损周围皮肤的直接免疫荧光检查对完整诊断都是必要的。自身免疫性大疱性疾病可单独影响皮肤和黏膜，但通常同时影响两者。青少年患者的疾病特征与成人相似；然而，在青春期，生物和社会发育的中断尤其令人关注。虽然全身性皮质类固醇激素已被用于成功治疗大多数病例，但为了获得充分的控制，通常需要长期使用。治疗的不良反应在青少年时期发生的荷尔蒙变化、身体和精神成长以及社会文化发展的这个关键时期可能会产生毁灭性的影响。必须设计新的治疗方法来充分治疗青少年患者，同时限制严重的不良反应。
