Monarca S, Pool-Zobel B L, Rizzi R, Klein P, Schmezer P, Piatti E, Pasquini R, De Fusco R, Biscardi D
Chair of Environmental Health, School of Medicine, University of Brescia, Italy.
Mutat Res. 1991 Feb;262(2):85-92. doi: 10.1016/0165-7992(91)90112-h.
Dimethyl terephthalate (DMTP), the para configuration of dimethyl phthalate, is one of the basic monomers used in the synthesis of polyethylene terephthalate (PET) plastics. Human exposure to DMTP may primarily occur during the manufacture of PET fibers and films. The mutagenic potential of dimethyl terephthalate was evaluated using a battery of in vitro short-term tests: the Ames test; DNA single-strand break assays in CO60 cells and in primary rat hepatocytes; UDS in HeLa cells; chromosome aberration and micronucleus assays in human peripheral blood lymphocytes; selective DNA amplification in CO60 and in Syrian hamster embryo cells. The results of this battery of in vitro assays clearly show that DMTP is nongenotoxic. By contrast, other authors have found DMTP to be an in vivo clastogenic compound and suggested that the mechanisms involved in these in vivo effects seem to have nothing in common with genotoxicity and are still unknown.
对苯二甲酸二甲酯（DMTP）是邻苯二甲酸二甲酯的对位异构体，是用于合成聚对苯二甲酸乙二酯（PET）塑料的基本单体之一。人类接触DMTP主要可能发生在PET纤维和薄膜的制造过程中。使用一系列体外短期试验评估了对苯二甲酸二甲酯的致突变潜力：艾姆斯试验；CO60细胞和原代大鼠肝细胞中的DNA单链断裂试验；HeLa细胞中的UDS；人类外周血淋巴细胞中的染色体畸变和微核试验；CO60和叙利亚仓鼠胚胎细胞中的选择性DNA扩增。这一系列体外试验的结果清楚地表明，DMTP无基因毒性。相比之下，其他作者发现DMTP是一种体内致断裂化合物，并表明这些体内效应所涉及的机制似乎与基因毒性毫无共同之处，并且仍然未知。
