Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA.
Leuk Lymphoma. 2010 Jan;51(1):10-9. doi: 10.3109/10428190903370346.
Our knowledge regarding the nature and function of 'hematogones' has evolved considerably, since the initial description more than 70 years ago. Once considered the 'mystery cells' of the bone marrow, major advances in immunology and flow cytometry have enabled us to better characterize these cells and recognize them as physiologic precursors of B-cells. In this review, we describe the morphologic and phenotypic characteristics and clinical relevance of hematogones, and report recent advances in our understanding and knowledge of these cells as they relate to physiologic and different pathologic conditions.
我们对‘造血祖细胞’的本质和功能的认识，自 70 多年前的首次描述以来已经有了相当大的发展。曾经被认为是骨髓中的‘神秘细胞’，免疫学和流式细胞术的重大进展使我们能够更好地描述这些细胞，并将其识别为 B 细胞的生理性前体细胞。在这篇综述中，我们描述了造血祖细胞的形态学和表型特征以及临床相关性，并报告了我们对这些细胞的理解和认识的最新进展，包括它们与生理和不同病理状况的关系。
